The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)
Ramya T. Kolli, T. D. K. S. C. Gunasekara, Matthew W. Foster, Sitaramaraju Adduri, Anna Strasma, Christina Wyatt, Nagarjun V. Konduru, P. Mangala C.S. De Silva, Nishad Jayasundara
Abstract
CKDu is a global health concern debilitating a number of tropical rural farming communities. In the absence of typical risk factors like diabetes and hypertension and the lack of molecular markers, it is crucial to identify potential early disease markers. Here, we detail the first urinary proteome profile to distinguish CKDu from CKD. Our data and in silico pathway analyses infer the roles of mitochondrial, lysosomal, and protein reabsorption processes in disease onset and progression.
Topics & Concepts
ReabsorptionKidney diseaseProteomeBiologyKidneyUrinary systemInternal medicineEndocrinologyMedicineBiochemistryChronic Kidney Disease and DiabetesDialysis and Renal Disease ManagementIron Metabolism and Disorders