Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain
Jessica Peterson, Larissa J. Strath, Chavier Laffitte Nodarse, Asha Rani, Zhiguang Huo, Lingsong Meng, Sean Yoder, James H. Cole, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz‐Almeida
Abstract
=0.010). Exploratory analysis revealed that DNAmGrimAge-difference mediated GCPS pain impact, GCPS pain severity, and pain-related disability scores on Brain-PAD. Based upon the current study findings, we suggest that pain could be a driver for accelerated brain aging via epigenome interactions.
Topics & Concepts
Brain agingKnee painChronic painAging brainMedicineEpigeneticsInternal medicinePhysical therapyDiseaseBiologyOsteoarthritisPathologyAlternative medicineBiochemistryGenePediatric Pain Management TechniquesPain Management and Opioid UseMusculoskeletal pain and rehabilitation