LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis
Yansheng Li, Xing Liu, Xiaoteng Cui, Yanli Tan, Qixue Wang, Yunfei Wang, Can Xu, Chuan Fang, Chunsheng Kang
Abstract
PRADX acts as a cancer driver and may serve as a potential therapeutic target for glioblastoma and colon adenocarcinoma.
Topics & Concepts
CarcinogenesisNF-κBCancer researchNFKB1Cell biologyChemistrySignal transductionBiologyTranscription factorCancerGeneticsGeneBiochemistryCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing