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Visible-Light-Mediated Access to Phosphate Esters

Alya Inial, Fabrice Morlet‐Savary, Jacques Lalevée, Annie−Claude Gaumont, Sami Lakhdar

2020Organic Letters29 citationsDOI

Abstract

We report herein a practically simple visible-light photocatalytic approach for the synthesis of a large variety of phosphate esters through the combination of N-alkoxypyridinium salts and phosphites under mild conditions. The scope of the reaction is broad and the protocol was successfully applied to the synthesis of biologically relevant structures. Quantum yield measurements, as well as EPR experiments, allowed the suggestion of a reasonable reaction mechanism.

Topics & Concepts

ChemistryYield (engineering)PhotocatalysisCombinatorial chemistryVisible spectrumPhosphateReaction conditionsScope (computer science)Electron paramagnetic resonanceQuantum yieldPhotochemistryNanotechnologyOrganic chemistryCatalysisOptoelectronicsComputer scienceProgramming languageMaterials scienceQuantum mechanicsMetallurgyNuclear magnetic resonanceFluorescencePhysicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions
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