The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis
Yapeng Wang, Mou Peng, Yawen Zhong, Wei Xiong, Liang Zhu, Xin Jin
Topics & Concepts
SunitinibClear cell renal cell carcinomaCancer researchBiologyUbiquitin ligaseProtein kinase BTyrosine-kinase inhibitorMAPK/ERK pathwayCarcinogenesisPhosphorylationCancerUbiquitinCell biologyInternal medicineRenal cell carcinomaMedicineBiochemistryGeneticsGeneRenal cell carcinoma treatmentUbiquitin and proteasome pathwaysCancer-related Molecular Pathways