Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46
Ichie Ojiro, Hiromi Nishio, Toyomi Yamazaki‐Ito, Shogo Nakano, Sohei Ito, Yoshikazu Toyohara, Tadahiro Hiramoto, Yuko Terada, Keisuke Ito
Abstract
Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.
Topics & Concepts
TasteReceptorChemistryAgonistBitter tastePharmacologyTransient receptor potential channelPeptideTaste receptorBiochemistryBiologyBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function StudiesAdvanced Chemical Sensor Technologies