Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
Abstract
shear stress conditions. Drug crossing assessment was performed with two chemotherapy drugs: doxorubicin, with a known poor BBB penetration, and temozolomide, conversely a specific drug for CNS disorders and able to cross the BBB, to validate the model predictive capability for drug crossing behavior. The proposed sensorized microfluidic device represents a significant advancement in BBB modeling, offering a versatile platform for CNS drug development, disease modeling, and personalized medicine.
Topics & Concepts
MicrofluidicsStructural integrityBlood–brain barrierBiomedical engineeringComputer scienceEngineeringNanotechnologyMaterials scienceNeuroscienceBiologyStructural engineeringCentral nervous system3D Printing in Biomedical ResearchBarrier Structure and Function StudiesInnovative Microfluidic and Catalytic Techniques Innovation