A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability
Daniela Begandt, H. Skye Comstra, Samuel A. Molina, Nenja Krüger, Claire A. Ruddiman, Yen‐Lin Chen, Xiaobin Chen, Lauren A. Biwer, Scott R. Johnstone, Alexander W. Lohman, Miranda E. Good, Leon J. DeLalio, Kwangseok Hong, Hannah M. Bacon, Zhen Yan, Swapnil K. Sonkusare, Michael Koval, Brant E. Isakson
Abstract
channel TRPV4 downstream of Panx1 activation. Panx1-deficient mice resisted the pathologic effects of sepsis induced by cecal ligation and puncture on life span and lung vascular permeability. These data provide a targetable pathway with the potential to promote vein barrier function and prevent the deleterious effects of vascular leak in response to inflammation.
Topics & Concepts
PannexinPurinergic receptorCell biologyChemistrySignal transductionBiologyIntracellularConnexinGap junctionExtracellularConnexins and lens biologyAdvanced Glycation End Products researchHeme Oxygenase-1 and Carbon Monoxide