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Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Geoffrey M. Lynn, Christine Sedlik, Faezzah Baharom, Yaling Zhu, Ramiro A. Ramirez-Valdez, Vincent Coble, Kennedy K.S. Tobin, Sarah R. Nichols, Yaakov Itzkowitz, Neeha Zaidi, Joshua M. Gammon, Nicolas J. Blobel, Jordan Denizeau, Philippe De La Rochère, Brian J. Francica, Brennan Decker, Mateusz Maciejewski, Justin Cheung, Hidehiro Yamane, Margery Smelkinson, Joseph R. Francica, Richard Laga, Joshua D. Bernstock, Leonard W. Seymour, Charles G. Drake, Christopher M. Jewell, Olivier Lantz, Eliane Piaggio, Andrew S. Ishizuka, Robert A. Seder

2020Nature Biotechnology337 citationsDOIOpen Access PDF

Topics & Concepts

ConjugateAntigenPeptideImmunityCD8Cross-presentationVirologyChemistryCell biologyBiologyImmune systemImmunologyBiochemistryMHC class IMathematicsMathematical analysisImmunotherapy and Immune ResponsesAntimicrobial Peptides and Activitiesvaccines and immunoinformatics approaches
Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens | Litcius