Alkynes and Nitrogen Compounds: Useful Substrates for the Synthesis of Pyrazoles
José S. S. Neto, Gilson Zeni
Abstract
The easy preparation and functionalization of pyrazoles associated with their innumerable biological properties have made this class of N-heterocycles very attractive for the development of new synthetic routes and applications. The cyclization reactions of alkynes and nitrogen compounds represent a powerful tool for the preparation of pyrazoles. This Review covers the recent advances in the preparation of pyrazoles by reacting alkynes and nitrogen compounds under transition-metal-catalyzed or metal-free conditions.
Topics & Concepts
NitrogenSurface modificationCombinatorial chemistryChemistryOrganic chemistryCatalysisMetalNanotechnologyMaterials sciencePhysical chemistryClick Chemistry and ApplicationsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods