Sequential single-enzyme oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid by an engineered lanthanide-dependent alcohol dehydrogenase
Ke Liu, Ling Jiang, Lun Wang, Qunfeng Zhang, Lirong Yang, Jianping Wu, Haoran Yu
Abstract
A lanthanide-dependent alcohol dehydrogenase, PedH, was identified, which possessed the rare ability to continuously oxidize HMF to produce FDCA. A fully automated workflow was developed to modify PedH, resulting in an increased yield of FDCA.
Topics & Concepts
Alcohol dehydrogenaseLanthanideChemistryEnzymeAlcohol oxidoreductaseAlcoholDehydrogenaseAlcohol oxidation5-hydroxymethylfurfuralOrganic chemistryBiochemistryCatalysisIonNAD+ kinaseCatalysis for Biomass ConversionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion