Copper(I)‐Catalyzed [4+2] Oxidative Annulation of <i>α</i>,<i>β</i>‐Unsaturated Ketoxime Acetates with Cyclopropanols toward Functional Pyridines
Qinghuan Wu, Gaochen Xu, Yuguang Li, Lei Shen, Zheng Fang, Jindian Duan, Kai Guo
Abstract
Abstract A Cu(I)‐catalyzed [4+2] oxidative annulation of α , β ‐unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis of 2,4,5‐trisubstituted pyridines in 28–76% yields. This method employs cyclopropanols as C2 synthons and features various functional group compatibility and gram‐scale synthesis. In addition, a plausible reaction pathway was proposed based on the mechanism studies.
Topics & Concepts
ChemistrySynthonAnnulationCatalysisOxidative phosphorylationFunctional groupMedicinal chemistryOrganic chemistryCombinatorial chemistryBiochemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation