B-cell acute lymphoblastic leukemia-related microRNAs: uncovering their diverse and special roles.
Mengqi Lv, Shicong Zhu, Hongling Peng, Zhao Cheng, Guangsen Zhang, Zhihua Wang
Abstract
B-cell acute lymphoblastic leukemia (B-ALL) is a common type of hematologic malignancy characterized by the uncontrolled growth of immature B lymphocytes. Genomics, transcriptomics, and proteomics at different levels contribute to early diagnosis and can thereby provide better treatment for cancer. MicroRNAs (miRNAs) are conducive to the diagnosis and treatment of patients with B-ALL. Moreover, evidence suggests that runaway miRNAs and exosomes containing miRNA may be involved in the occurrence of B-ALL, which can then be used as potential biomarkers. This review summarizes the role of miRNAs in the pathogenesis, diagnosis, prognosis, and treatment of B-ALL.
Topics & Concepts
microRNAMicrovesiclesCancer researchMalignancyTranscriptomeLeukemiaPathogenesisLymphoblastic LeukemiaCancerB cellBiologyMedicineGeneComputational biologyBioinformaticsImmunologyGeneticsGene expressionAntibodyMicroRNA in disease regulationExtracellular vesicles in disease