Treatment horizon in multiple myeloma
Cinnie Yentia Soekojo, Wee Joo Chng
Abstract
OBJECTIVES: This paper reviews current and emerging therapies for multiple myeloma (MM). METHODS: Narrative review. RESULTS: MM is a complex, heterogenous condition, and in recent years there has been an expansion in the number and range of treatments. Several new treatment approaches, including enhanced monoclonal antibodies, antibody-drug conjugates, bispecific T-cell engagers, and chimeric antigen-T-cell therapy are under development. CONCLUSIONS: The emergence of new treatments that aim to tackle MM-associated immune dysfunction has led to improvements in overall survival.
Topics & Concepts
Multiple myelomaChimeric antigen receptorMedicineMonoclonal antibodyAntibodyNarrative reviewAntigenImmune systemImmunologyImmunotherapyIntensive care medicineMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsPeptidase Inhibition and Analysis