Ru(II)-Catalyzed C–H Functionalization of <i>N</i>-Hydroxyoximes with 1,3-Diynes Unveils a Regioselective Disparity
Shreemoyee Kumar, Akshay M. Nair, Chandra M. R. Volla
Abstract
A highly selective and convenient Ru(II)-catalyzed C-H bond activation protocol has been demonstrated to access 4-alkynylated isoquinolines, which was so far elusive from 1,3-diynes. Subsequently, the same protocol was extended to furnish various 4-4'-biisoquinoline motifs. The key feature of this work is the regioselective disparity observed during the migratory insertion of an organoruthenium metallacycle with the C3-C4 triple bond of 1,3-diynes resulting in divergent products as compared to the existing literature.
Topics & Concepts
RegioselectivityChemistrySurface modificationCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Alkyne Reactions