The Clostridioides difficile Cysteine-Rich Exosporium Morphogenetic Protein, CdeC, Exhibits Self-Assembly Properties That Lead to Organized Inclusion Bodies in Escherichia coli
A. Romero, Scarlett Troncoso-Cotal, Enzo Guerrero-Araya, Daniel Paredes‐Sabja
Abstract
The endospore of Clostridioides difficile is the vehicle for transmission and persistence of the pathogen, and, specifically, the exosporium is the first contact between the host and the spore. The underlying mechanisms that govern exosporium assembly in C. difficile remain understudied, in part due to difficulties in obtaining pure soluble recombinant proteins of the C. difficile exosporium. Understanding the exosporium assembly’s molecular bases may be essential to developing new therapies against C. difficile infection.
Topics & Concepts
ClostridioidesMicrobiologyRecombinant DNACysteineEscherichia coliBiologyPathogenGeneticsBiochemistryGeneEnzymeClostridium difficile and Clostridium perfringens researchViral gastroenteritis research and epidemiologyAntimicrobial Resistance in Staphylococcus