Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation
Roman Sloutsky, Noelle Dziedzic, Matthew J. Dunn, Rachel M. Bates, Ana P. Torres‐Ocampo, Sivakumar Boopathy, Brendan Page, John G. Weeks, Luke H. Chao, Margaret M. Stratton
Abstract
/CaM sensitivity in CaMKII is homolog dependent and includes substantial contributions from the hub domain. Our sequencing approach, combined with biochemistry, provides insights into understanding the complex pool of endogenous CaMKII splice variants.
Topics & Concepts
Allosteric regulationHippocampal formationCell biologyKinaseBiologyNeuroscienceChemistryGeneticsReceptorATP Synthase and ATPases ResearchNeuroscience and Neuropharmacology ResearchMitochondrial Function and Pathology