How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in <i>Bacillus subtilis</i>
Janek Meißner, Thorben Schramm, Ben Hoßbach, Katharina Sophie Stark, Hannes Link, Jörg Stülke
Abstract
Amino acids are building blocks for protein biosynthesis in each living cell. However, due to their reactivity and the similarity between several amino acids, they may also be involved in harmful reactions or in noncognate interactions and thus may be toxic. Bacillus subtilis can deal with otherwise toxic histidine by overexpressing the bipartite amino acid exporter AzlCD.
Topics & Concepts
OperonAmino acidBiologyHistidineBacillus subtilisBiochemistryGeneMutantBacteriaGeneticsBacterial Genetics and BiotechnologyBacteriophages and microbial interactionsAntibiotic Resistance in Bacteria