Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M
Moustafa O. Aboelez, Moumen S. Kamel, Amany Belal, Ahmed Abdelaziz, Mohammed A. S. Abourehab, H. Abdel‐Ghany, Mohamed A. El Hamd, Mahmoud Abd El Aleem Ali Ali El‐Remaily
Topics & Concepts
ErlotinibCytotoxicityGefitinibChemistryA549 cellMTT assayIn vitroEpidermal growth factor receptorIC50Cancer cellTyrosine kinaseEGFR inhibitorsStereochemistryCombinatorial chemistryPharmacologyBiochemistryCancerReceptorBiologyGeneticsSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applications