The monkeypox outbreak in 2022: adaptive evolution associated with APOBEC3 may account for
Yangzhen Chen, Maochen Li, Huahao Fan
Abstract
In a recent study published on Nature Medicine, Isidro, J et al. attempted to explore the potential causes of the recent monkeypox outbreak in 2022, 1 which has been declared as a Public Health Emergency of International Concern (PHEIC). The genetic characterization study based on shotgun metagenomics suggested that the mutational bias (from GA to AA or TC to TT) in monkeypox genomes driven by apolipoprotein B mRNAediting catalytic polypeptide-like 3 (APOBEC3) enzyme might account for the PHEIC.
Topics & Concepts
MonkeypoxVirologyOutbreakBiologyEvolutionary biologyComputational biologyGeneticsVacciniaGeneRecombinant DNAPoxvirus research and outbreaksPlant Virus Research StudiesHerpesvirus Infections and Treatments