ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7
Yiling Meng, Lei Bian, Meichao Zhang, Pingting Zhou, Suning Zhang, Yingxia Ying, Sunhu Yang, Yuanhua Liu, Yuan Yao, Dong Li
Abstract
. ISG15 promotes progression and resistance to therapy in PC cells by binding to ATG7, reducing its degradation, and thereby leading to enhanced autophagy in PC cells. ISG15 may be used as both a potential diagnosis marker and sensitizer for chemotherapeutics such as Gemcitabine during PC intervention.
Topics & Concepts
ISG15GemcitabinePancreatic cancerCancer researchAutophagyCancerApoptosisChemotherapyBiologyMedicineInternal medicineOncologyUbiquitinGeneGeneticsImmunotherapy and Immune ResponsesCancer Research and TreatmentsCancer Mechanisms and Therapy