Novel Musculoskeletal and Orthopedic Applications of 18F-Sodium Fluoride PET
William Raynor, Austin J. Borja, Emily Hancin, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim
Abstract
The bone-seeking properties of 18 F-sodium fluoride (NaF) were first described in 1962 by Blau and colleagues, 1 who used this positron-emitting radiotracer in skeletal scintigraphy. Both high uptake by bone and rapid plasma clearance of NaF were determined to be advantages in imaging skeletal metabolism. One hour after NaF is administered intravenously, only 10% remains in the plasma compartment because of a first-pass
Topics & Concepts
MedicineProstate cancerSodium fluorideOrthopedic surgeryMagnetic resonance imagingPET-CTCancerPet imagingPositron emission tomographyFluorideRadiologyNuclear medicineInternal medicineSurgeryChemistryInorganic chemistryMedical Imaging Techniques and ApplicationsBone health and treatmentsRadiopharmaceutical Chemistry and Applications