Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform
Chi‐An Cheng, Wei Chen, Le Zhang, Holden H. Wu, Jeffrey I. Zink
Abstract
We developed a theranostic approach exemplifying a concept called an "exchange method" that controls and "images" drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound. The controllable amount of released drug and therapeutic efficacy can be self-reported by associated MRI contrast changes in solution and in cells.
Topics & Concepts
Magnetic resonance imagingNanoparticleUltrasoundMaterials scienceIntensity (physics)Core (optical fiber)Drug deliveryNuclear magnetic resonanceHigh-intensity focused ultrasoundShell (structure)Magnetic nanoparticlesNanotechnologyResonance (particle physics)RadiologyMedicineOpticsComposite materialPhysicsAtomic physicsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsUltrasound and Hyperthermia Applications