Developing Photoaffinity Probes for Dopamine Receptor D <sub>2</sub> to Determine Targets of Parkinson’s Disease Drugs
Spencer T. Kim, Emma J. Doukmak, Raymond G. Flax, Dylan J. Gray, Victoria Zirimu, Ebbing P. de Jong, Rachel C. Steinhardt
Abstract
(DRD1) signaling networks. Follow-up analysis may yield insights into how this pathway relates specifically to Parkinson's disease symptoms or provide new targets for treatments. This work reinforces the notion that the combination of chemical biology and omics-based approaches provides a broad picture of a molecule's "interactome" and may also give insight into the pleiotropy of effects observed for a drug or perhaps indicate new applications.
Topics & Concepts
ReceptorDopaminergicDopamine receptor D2Dopamine receptorDopamineNeuroscienceG protein-coupled receptorBiologyDrug discoveryBiochemistryChemistryPharmacologyReceptor Mechanisms and SignalingClick Chemistry and ApplicationsBiotin and Related Studies