Aptamer-Functionalized Ce<sup>4+</sup>-Ion-Modified C-Dots: Peroxidase Mimicking Aptananozymes for the Oxidation of Dopamine and Cytotoxic Effects toward Cancer Cells
Yu Ouyang, Michael Fadeev, Pu Zhang, Raanan Carmieli, Yang Sung Sohn, Ola Karmi, Yunlong Qin, Xinghua Chen, Rachel Nechushtai, Itamar Willner
Abstract
-ion-modified C-dots reveals selective cytotoxicity toward the cancer cells. In vivo experiments reveal that the aptamer-functionalized nanoparticles inhibit MDA-MB-231 tumor growth.
Topics & Concepts
AptamerMaterials scienceCatalysisCancer cellPeroxidaseIonNanoparticleNanotechnologyCombinatorial chemistryBiophysicsChemistryCancerEnzymeBiochemistryBiologyOrganic chemistryMolecular biologyGeneticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and Applications