PIP2 regulation of TRPC5 channel activation and desensitization
Mehek Ningoo, Leigh D. Plant, Anna Greka, Diomedes E. Logothetis
Abstract
controls both the PKC-mediated inhibition and the DAG- and lanthanide-mediated activation of TRPC5 currents via control of gating rather than channel cell surface density. These mechanistic insights promise to aid in the development of more selective and precise inhibitors to block TRPC5 channel activity and illuminate new opportunities for targeted therapies for a group of chronic kidney diseases for which there is currently a great unmet need.
Topics & Concepts
Desensitization (medicine)TRPC5ChemistryBiophysicsCell biologyIon channelBiochemistryBiologyReceptorTRPC1Ion Channels and ReceptorsIon channel regulation and functionRespiratory and Cough-Related Research