Expanding the toolbox of Baeyer–Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides
Jingyue Wu, Silvia Anselmi, Alexandra T. P. Carvalho, Jill Caswell, Derek J. Quinn, Thomas S. Moody, Daniele Castagnolo
Abstract
Two new monooxygenase biocatalysts, BVMO145 and FMO401 from Almac library, catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions.
Topics & Concepts
MonooxygenaseBiocatalysisFlavin-containing monooxygenaseChemistryFlavin groupCatalysisStereochemistryOrganic chemistryEnzymeCytochrome P450Reaction mechanismChemical Synthesis and ReactionsEnzyme Catalysis and ImmobilizationSulfur-Based Synthesis Techniques