Ni-Catalyzed Asymmetric C–P Cross-Coupling Reaction for the Synthesis of Chiral Heterocyclic Phosphine Oxides
Ranran Cui, Yinqi Wang, Liyan Yuwen, Gao Li, Zhuo Huang, Wei-Han Wang, Qing‐Wei Zhang
Abstract
Nickel performs excellently in C-C and C-X cross-coupling reactions. Here, we disclose a Ni(II)-catalyzed asymmetric C-P cross-coupling reaction to afford valuable chiral heterocyclic tertiary phosphine oxides. The method is mild and efficient, which invokes a self-sustained nickel catalytic cycle without an external reductant, light irradiation, or electricity.
Topics & Concepts
ChemistryCatalysisPhosphineNickelCoupling reactionCoupling (piping)Catalytic cycleCombinatorial chemistryMedicinal chemistryOrganic chemistryMetallurgyMaterials scienceAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions