Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2
Marti Cabanes‐Creus, Adrian Westhaus, Renina Gale Navarro, Grober Baltazar, Erhua Zhu, Anais K. Amaya, Sophia H.Y. Liao, Suzanne Scott, Erwan Sallard, Kimberley L. Dilworth, Arkadiusz Rybicki, Matthieu Drouyer, Claus V. Hallwirth, Antonette Bennett, Giorgia Santilli, Adrian J. Thrasher, Mavis Agbandje‐McKenna, Ian E. Alexander, Leszek Lisowski
Abstract
. The insights gained through this study can have powerful implications for studies into AAV biology and capsid development for preclinical and clinical applications targeting liver and other organs.
Topics & Concepts
In vivoHeparan sulfateTransduction (biophysics)Cell biologyProteoglycanSignal transductionSyndecan 1ChemistryAttenuationBiologyGlycosaminoglycanBiochemistryExtracellular matrixCellGeneticsPhysicsOpticsVirus-based gene therapy researchRNA Interference and Gene DeliveryXenotransplantation and immune response