The Fe(<scp>iii</scp>)-catalyzed decarboxylative cycloaddition of β-ketoacids and 2<i>H</i>-azirines for the synthesis of pyrrole derivatives
Haipeng Hu, Wang Cuilin, Han Lai, Siyuan Wang, Hai‐Liang Ni, Wenhao Yu, Peng Cao
Abstract
An Fe(<sc>iii</sc>)-catalyzed Mannich/decarboxylative ring expansion reaction to generate pyrrole derivatives has been achieved using Fe(OTf)<sub>3</sub> as the catalyst. A series of pyrrole derivatives was obtained in moderate to excellent yields.
Topics & Concepts
ChemistryPyrroleCatalysisCycloadditionMannich reactionMedicinal chemistryReaction conditionsCombinatorial chemistryOrganic chemistrySynthesis and Characterization of PyrrolesFluorine in Organic ChemistrySynthesis and Catalytic Reactions