Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin
Ekaterina V. Razuvaeva, Kirill T. Kalinin, Nikita G. Sedush, Alexey A. Nazarov, Dmitry S. Volkov, С. Н. Чвалун
Abstract
Spherical nanoparticles based on the biocompatible and biodegradable poly(d,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.
Topics & Concepts
OxaliplatinChemistryCytotoxicityCopolymerNanoparticleBiocompatible materialIn vitroLactideNuclear chemistryChemical engineeringPolymer chemistryNanotechnologyOrganic chemistryBiomedical engineeringBiochemistryCancerPolymerMaterials scienceColorectal cancerEngineeringInternal medicineMedicineNanoparticle-Based Drug DeliveryCancer Treatment and Pharmacologybiodegradable polymer synthesis and properties