Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance
Fei Cao, Yulong Li, Furong Ma, Zumei Wu, Zheshen Li, Zhe‐Sheng Chen, Xiangdong Cheng, Jiang‐Jiang Qin, Jinyun Dong
Abstract
is the most effective P-gp inhibitor among them with low toxicity and high MDR reversal activity, which provided a fundamental structural reference for further discovery of novel, effective, and non-toxic P-gp inhibitors.
Topics & Concepts
ReversingP-glycoproteinMultiple drug resistancePharmacologyChemistryMedicineBiochemistryMaterials scienceComposite materialAntibioticsDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsComputational Drug Discovery Methods