MiR-4644 is upregulated in plasma exosomes of bladder cancer patients and promotes bladder cancer progression by targeting UBIAD1.

Abstract

assays demonstrated that miR-4644 mimic promoted, whereas miR-4644 inhibitor suppressed BCa cell proliferation and invasion. miR-4644 negatively regulated expression of UBIAD1 (UbiA prenyltransferase domain-containing protein 1) by directly binding to its 3'-UTR region. UBIAD1 overexpression effectively abrogated the promoting effects of miR-4644 mimic on BCa proliferation, migration, and invasion. Additionally, intratumoral injection of miR-4644 antagomir downregulated miR-4644 expression in tumors and suppressed tumorigenesis in mouse xenografts. Collectively, miR-4644 promotes BCa progression by targeting UBIAD1. miR-4644 may be an important therapeutic target for BCa treatment.

Topics & Concepts