Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells
Shinichi Terada, Satoshi Tsunetoh, Yoshimichi Tanaka, Tomohito Tanaka, Hideki Kashiwagi, Takushi Takata, Shinji Kawabata, Minoru Suzuki, Masahide Ohmichi
Abstract
There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.
Topics & Concepts
Neutron captureBoronCervical cancerRadiochemistryIn vivoCervical carcinomaCancerNuclear medicineNeutron irradiationIrradiationBiodistributionMedicineNeutron temperatureChemistryOncologyCancer researchNeutronIn vitroInternal medicineBiologyBiochemistryQuantum mechanicsNuclear physicsBiotechnologyOrganic chemistryPhysicsBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsAmino Acid Enzymes and Metabolism