Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies
Muhammad Aamir Javed, Saba Bibi, Muhammad Saeed Jan, Muhammad Ikram, Asma Zaidi, Umar Farooq, Abdul Sadiq, Umer Rashid
Abstract
dose. In docking studies three-dimensional construction and interaction with key residues of all the studied biological macromolecules helped us to explain the experimental results.
Topics & Concepts
CholinesteraseCyclooxygenaseMonoamine oxidasePharmacologyDiclofenacChemistryMonoamine oxidase BLipoxygenaseConcomitantMedicineEnzymeBiochemistryInternal medicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection