<i>Senegalia macrostachya</i> seed polysaccharides attenuate inflammation-induced intestinal epithelial barrier dysfunction in a Caco-2 and RAW264.7 macrophage co-culture model by inhibiting the NF-κB/MLCK pathway
Abel Wend‐Soo Zongo, Daniel Zogona, Mahmoud Youssef, Shuxin Ye, Fuchao Zhan, Jing Li, Bin Li
Abstract
Senegalia macrostachya seed polysaccharides improved the Caco-2 cell monolayer integrity from the inflammatory insult. SMSP2 treatment lowered the inflammatory cytokine release, increased TJ proteins, and downregulated the NF-κB/MLCK pathway.
Topics & Concepts
OccludinTight junctionBarrier functionMyosin light-chain kinaseInflammationNitric oxide synthaseBiologyTumor necrosis factor alphaProinflammatory cytokineCell biologyDownregulation and upregulationCaco-2LipopolysaccharideMolecular biologyPhosphorylationNitric oxideImmunologyBiochemistryEndocrinologyIn vitroGeneBarrier Structure and Function StudiesWound Healing and TreatmentsNeurological Disease Mechanisms and Treatments