An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells
Viviana Donoso-Bustamante, Edgar A. Borrego, Yareli Schiaffino-Bustamante, Denisse A. Gutiérrez, Juan Pablo Millas-Vargas, Sebastián Fuentes-Retamal, Pablo Correa, Ileana Carrillo, Renato J. Aguilera, Dante Miranda, Ignacio Chávez‐Báez, Rodrigo Pulgar, Félix A. Urra, Armando Varela‐Ramírez, Ramiro Araya‐Maturana
Topics & Concepts
ChemistryLeukemiaCancer cellCancer researchProgrammed cell deathMitochondrionOligomycinApoptosisCell culturePharmacologyInner mitochondrial membraneOxidative phosphorylationAcute promyelocytic leukemiaBiochemistryCancerBiologyRetinoic acidImmunologyMedicineInternal medicineATPaseEnzymeGeneGeneticsHistone Deacetylase Inhibitors ResearchGenomics, phytochemicals, and oxidative stressAutophagy in Disease and Therapy