Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore
Krzysztof Fink, Jakub Cebula, Zdeněk Tošner, Mateusz Psurski, Mariusz Uchman, Tomasz M. Goszczyński
Abstract
experiments. These findings demonstrate that COSAN is a DNA-neutral pharmacophore, thus confirming the general safety and biocompatibility of metallacarboranes and opening up new opportunities for further developing metallacarborane-based drugs.
Topics & Concepts
PharmacophoreCobaltDNAChemistryCytotoxicityCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryIn vitroBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsMetal complexes synthesis and properties