Synthesis, docking studies, in silico ADMET predictions, DFT calculations, and photophysical properties of thiazole-anthracene hybrids as potent EGFR inhibitors
Rambabu Palabindela, Ramakrishna Bodapati, Prabhakar Myadaraveni, Ramesh Gondru, Mamatha Kasula
Topics & Concepts
ChemistryErlotinibThiazoleDocking (animal)Lead compoundIn silicoStereochemistryDensity functional theoryA549 cellEGFR inhibitorsCombinatorial chemistryIn vitroComputational chemistryEpidermal growth factor receptorBiochemistryReceptorMedicineNursingGeneSynthesis and biological activityMetal complexes synthesis and propertiesComputational Drug Discovery Methods