Identifying biophysical assays and <i>in silico</i> properties that enrich for slow clearance in clinical-stage therapeutic antibodies
Boris Grinshpun, Nels Thorsteinson, Joao NS Pereira, Friedrich Rippmann, D.P. Nannemann, Vanita D. Sood, Yves Fomekong Nanfack
Abstract
estimated isoelectric point can discriminate fast and slow clearing antibodies, extending previous observations on preclinical clearance. This provides a simple yet powerful approach to select antibodies with desirable PK during early-stage screening.
Topics & Concepts
In silicoAntibodyMonoclonal antibodyComputational biologyDrug discoveryBiologyChemistryBioinformaticsImmunologyBiochemistryGeneMonoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical MethodsProtein purification and stability