Discovery of novel 1,2,4-triazole tethered β-hydroxy sulfides as bacterial tyrosinase inhibitors: synthesis and biophysical evaluation through <i>in vitro</i> and <i>in silico</i> approaches
Sadaf Saeed, Muhammad Jawwad Saif, Ameer Fawad Zahoor, Hina Tabassum, Shagufta Kamal, Shah Faisal, Rabia Ashraf, Samreen Gul Khan, Usman Nazeer, Ali Irfan, M. A. Bhat
Abstract
anti-tyrosinase assay results; therefore, the molecule 11c can be the lead bacterial tyrosinase inhibitor as well as the antibacterial agent against both types of bacterial strains after suitable structural modifications.
Topics & Concepts
TyrosinaseIn silicoChemistryIn vitroCombinatorial chemistryTriazolePotencyStereochemistryBiochemistryEnzymeOrganic chemistryGenemelanin and skin pigmentationRNA regulation and diseaseBiochemical Analysis and Sensing Techniques