An <i>In Vivo</i> Model of Echovirus-Induced Meningitis Defines the Differential Roles of Type I and Type III Interferon Signaling in Central Nervous System Infection
Alexandra I. Wells, Carolyn B. Coyne
Abstract
models that recapitulate this aspect of echovirus pathogenesis. Here, we establish a neonatal mouse model of echovirus-induced aseptic meningitis and show that expression of the human homologue of the FcRn, the primary receptor for echoviruses, and ablation of type I IFN signaling are required to recapitulate echovirus-induced meningitis and clinical disease. These findings provide key insights into the host factors that control echovirus-induced meningitis and a model that could be used to test anti-echovirus therapeutics.
Topics & Concepts
EchovirusAseptic meningitisBiologyMeningitisImmunologyVirologyVirusMedicineEnterovirusCerebrospinal fluidNeurosciencePsychiatryViral Infections and Immunology Researchinterferon and immune responsesCytomegalovirus and herpesvirus research