HSPA5 Promotes Attachment and Internalization of Porcine Epidemic Diarrhea Virus through Interaction with the Spike Protein and the Endo-/Lysosomal Pathway
Chuanjie Zhou, Yunchao Liu, Qiang Wei, Yumei Chen, Suzhen Yang, Anchun Cheng, Gaiping Zhang
Abstract
PEDV infection causes severe piglet mortality and threatens the global pig industry. However, the complex invasion mechanism of PEDV makes its prevention and control difficult. Here, we determined that HSPA5 is a novel target for PEDV which interacts with its S protein and is involved in viral attachment and internalization, influencing its transport via the endo-/lysosomal pathway. Our work extends knowledge about the relationship between the PEDV S and host proteins and provides a new therapeutic target against PEDV infection.
Topics & Concepts
Porcine epidemic diarrhea virusInternalizationBiologyCoronavirusVirologyCell biologyViral proteinViral replicationHeat shock proteinVirusGeneticsCellGeneCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)DiseasePathologyAnimal Virus Infections StudiesVirus-based gene therapy researchAnimal Disease Management and Epidemiology