Unexpected expression of mismatch repair protein is more commonly seen with pathogenic missense than with other mutations in Lynch syndrome
Wei Chen, Heather Hampel, Rachel Pearlman, Dan Jones, Weiqiang Zhao, Mohammed Alsomali, Deborah A. Knight, Wendy L. Frankel
Topics & Concepts
Missense mutationLynch syndromeDNA mismatch repairGermline mutationImmunohistochemistryBiologyMutationGermlineColorectal cancerCancer researchGeneticsCancerGeneImmunologyGenetic factors in colorectal cancerColorectal Cancer Screening and DetectionCancer Genomics and Diagnostics