Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction
Raphaël Le Biannic, Romain Magnez, Frédérique Klupsch, Natascha Leleu‐Chavain, Bryan Thiroux, Morgane Tardy, Hassiba El Bouazzati, Xavier Dezitter, Nicolas Renault, Gérard Vergoten, Christian Bailly, Bruno Quesnel, Xavier Thuru, Régis Millet
Topics & Concepts
ChemistryMicroscale thermophoresisADMEFörster resonance energy transferSmall moleculeMonoclonal antibodyImmune checkpointPyrazoloneIn vitroCancer researchBiochemistryReceptorAntibodyFluorescenceImmunologyBlockadeBiologyPhysicsQuantum mechanicsCancer Immunotherapy and BiomarkersProtein Tyrosine PhosphatasesComputational Drug Discovery Methods