A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype
Qiong Zhao, Hui Chang, Jing Zheng, Ping Li, Lidan Ye, Ruolang Pan, Di Li, Jianzhong Shao, Robert Chunhua Zhao, Ye Chen
Abstract
Inflammatory bowel disease (IBD), a complex syndrome characterized by chronic inflammation of the gastrointestinal tract, is considered a global health problem, especially prevalent in western developed countries and with accelerating incidence in the developing world over the last decade. 1 To date, the primary etiology of IBD remains elusive. Accumulated evidence suggests a significant connection between intestinal inflammation and mitochondrial dysfunction. 2 , 3 Abnormalities in the structure and function of mitochondria have been observed in IBD patients and experimental models. 4 However, the pathophysiological roles of various mitochondrial components in IBD are mainly unknown, necessitating the development of novel animal models to delineate pathogenic genes and unravel related mechanisms.