FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma
Yunhong Xu, Jun Li, Kuikui Zhu, Yulan Zeng, Jing Chen, Xiaorong Dong, Sheng Zhang, Shuangbing Xu, Gang Wu
Abstract
. Moreover, we uncover that FIBP interacts with STAT3 to enhance its transcriptional activity, thereby inducing the expression of the downstream target gene EME1. Importantly, we demonstrate that the biological effects of FIBP are partially dependent on EME1 in lung adenocarcinoma. Our work reveals that FIBP modulates the STAT3/EME1 axis to drive lung cancer progression and radioresistance, indicating that targeting FIBP may be a novel intervention strategy for lung adenocarcinoma radiotherapy.
Topics & Concepts
RadioresistanceAdenocarcinomaCancer researchLung cancerDownregulation and upregulationBiologySTAT3In vivoRadiation therapyLungCancerMedicineGeneOncologyInternal medicineGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCytokine Signaling Pathways and Interactions