Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy
Yong‐Ke You, Weifeng Wu, Xiao‐Ru Huang, Hai-Di Li, Yeping Ren, Jincheng Zeng, Haiyong Chen, Hui Y. Lan
Abstract
Introduction and Aims: Elevated plasma levels of C-reactive protein (CRP) are closely associated with progressive renal injury in patients with chronic kidney disease (CKD). Here, we tested a hypothesis that CRP may promote renal fibrosis and inflammation via a TGF-/Smad3-dependent mechanism.
Topics & Concepts
InflammationFibrosisKidneyMedicineKidney diseaseFibronectinCancer researchInternal medicineEndocrinologyImmunologyBiologyCellGeneticsChronic Kidney Disease and DiabetesRenal and related cancersParathyroid Disorders and Treatments