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Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor

Qing-Zhu Fan, Ji Zhou, Yi‐Bao Zhu, Lianjun He, Dong‐Dong Miao, Shengpeng Zhang, Xiaoping Liu, Chao Zhang

2020Bioorganic Chemistry21 citationsDOI

Topics & Concepts

Thioredoxin reductaseChemistryCancer cellThioredoxinIndoleamine 2,3-dioxygenaseCancer immunotherapyReactive oxygen speciesCell growthCancer researchApoptosisBiochemistryEnzymeCancerImmunotherapyBiologyAmino acidGeneticsTryptophanTryptophan and brain disordersPharmacological Receptor Mechanisms and EffectsAdenosine and Purinergic Signaling
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor | Litcius