Synthesis, crystal structure, and antiviral evaluation of new imidazopyridine-schiff base derivatives: <i>in vitro</i> and <i>in silico</i> anti-HIV studies
Mohamed Azzouzi, Abderrahim Ait Ouchaoui, Omar Azougagh, Salah Eddine El Hadad, Mohamed Abou-Salama, Adyl Oussaid, Christophe Pannecouque, Taoufik Rohand
Abstract
against HIV-1 and HIV-2, respectively. Molecular docking studies were conducted to gain insights into the interaction mechanism of the synthesized compounds with HIV-1 reverse transcriptase. ADME analysis suggested acceptable pharmacokinetic profiles, though solubility remains a limitation for these compounds, highlighting the need for further structural modifications to enhance bioavailability and therapeutic potential.
Topics & Concepts
ImidazopyridineSchiff baseChemistryIn silicoADMEIn vitroPyridineCombinatorial chemistryHuman immunodeficiency virus (HIV)StereochemistryOrganic chemistryBiochemistryVirologyBiologyGeneSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsComputational Drug Discovery Methods